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The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]

Gonzalez-Franquesa A, Stocks B, Borg ML, et al.: Discovery of thymosin 4 as a human exerkine and growth factor

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